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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0e0b39b339f42dec9c770e3e5afe80ff2769a01f0b3532ac9317cd371770e109' 
  AND token = 'JCq5S89vApfenomm7PtvrNDxR5e4wNyqqqkDjp2L6o8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00125

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}