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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1d322263b1191936549b951c62185dc108a14bf5c04269fee7ee0f0c6d53b227' 
  AND token = '/Fz0Hf5CZufdm+t0u8DQUI8zIaxRwZnzwdN6rIyDIcE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00125

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}